Innate Direct Anticancer Effector Function of Human Immature Dendritic Cells. I. Involvement of an Apoptosis-Inducing Pathway1

@article{Janjic2002InnateDA,
  title={Innate Direct Anticancer Effector Function of Human Immature Dendritic Cells. I. Involvement of an Apoptosis-Inducing Pathway1},
  author={Bratislav M. Janjic and Ganwei Lu and Alexei Pimenov and Theresa L. Whiteside and Walter J. Storkus and Nikola L. Vujanovi{\'c}},
  journal={The Journal of Immunology},
  year={2002},
  volume={168},
  pages={1823 - 1830}
}
Dendritic cells (DCs) mediate cross-priming of tumor-specific T cells by acquiring tumor Ags from dead cancer cells. The process of cross-priming would be most economical and efficient if DCs also induce death of cancer cells. In this study, we demonstrate that normal human in vitro generated immature DCs consistently and efficiently induce apoptosis in cancer cell lines, freshly isolated noncultured cancer cells, and normal proliferating endothelial cells, but not in most normal cells. In… 
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Overall, the data demonstrate that DCs are fully equipped for an efficient direct apoptotic killing of cancer cells and suggest that this mechanism may play a critical role in both afferent and efferent anti-tumor immunity.
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