Innate Antiviral Responses by Means of TLR7-Mediated Recognition of Single-Stranded RNA
@article{Diebold2004InnateAR, title={Innate Antiviral Responses by Means of TLR7-Mediated Recognition of Single-Stranded RNA}, author={Sandra S Diebold and Tsuneyasu Kaisho and Hiroaki Hemmi and Shizuo Akira and Caetano Reis e Sousa}, journal={Science}, year={2004}, volume={303}, pages={1529 - 1531} }
Interferons (IFNs) are critical for protection from viral infection, but the pathways linking virus recognition to IFN induction remain poorly understood. Plasmacytoid dendritic cells produce vast amounts of IFN-α in response to the wild-type influenza virus. Here, we show that this requires endosomal recognition of influenza genomic RNA and signaling by means of Toll-like receptor 7 (TLR7) and MyD88. Single-stranded RNA (ssRNA) molecules of nonviral origin also induce TLR7-dependent production…
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