InlA Promotes Dissemination of Listeria monocytogenes to the Mesenteric Lymph Nodes during Food Borne Infection of Mice

@inproceedings{Ghanem2012InlAPD,
  title={InlA Promotes Dissemination of Listeria monocytogenes to the Mesenteric Lymph Nodes during Food Borne Infection of Mice},
  author={Elsa N. Bou Ghanem and Grant S. Jones and Tanya Myers-Morales and Pooja D. Patil and Achmad N. Hidayatullah and Sarah E F D'Orazio},
  booktitle={PLoS pathogens},
  year={2012}
}
Intestinal Listeria monocytogenes infection is not efficient in mice and this has been attributed to a low affinity interaction between the bacterial surface protein InlA and E-cadherin on murine intestinal epithelial cells. Previous studies using either transgenic mice expressing human E-cadherin or mouse-adapted L. monocytogenes expressing a modified InlA protein (InlA(m)) with high affinity for murine E-cadherin showed increased efficiency of intragastric infection. However, the large… CONTINUE READING