Inkjet Printing of Amphotericin B onto Biodegradable Microneedles Using Piezoelectric Inkjet Printing

@article{Boehm2013InkjetPO,
  title={Inkjet Printing of Amphotericin B onto Biodegradable Microneedles Using Piezoelectric Inkjet Printing},
  author={Ryan D. Boehm and Philip Rocco Miller and Wiley A. Schell and John R Perfect and Roger J. Narayan},
  journal={JOM},
  year={2013},
  volume={65},
  pages={525-533}
}
The delivery of amphotericin B, a pharmacologic agent with activity against a broad spectrum of fungi as well as against parasitic protozoa, has been complicated by the fact that amphotericin B exhibits poor solubility in aqueous solutions at physiologic pH levels. In this study, piezoelectric inkjet printing was used to modify the surfaces of Gantrez 169 BF microneedles (Ashland, Covington, KY). These amphotericin B-loaded microneedles demonstrated activity against Candida parapsilosis in a… CONTINUE READING