Ink4a and Arf differentially affect cell proliferation and neural stem cell self-renewal in Bmi1-deficient mice.

@article{Bruggeman2005Ink4aAA,
  title={Ink4a and Arf differentially affect cell proliferation and neural stem cell self-renewal in Bmi1-deficient mice.},
  author={Sophia W. M. Bruggeman and Merel E. Valk-Lingbeek and Petra M. van der Stoop and Jacqueline J L Jacobs and Karin Kieboom and Ellen Tanger and Danielle Hulsman and Carly Leung and Yvan Arsenijevic and Silvia Mari{\~n}o and Maarten van Lohuizen},
  journal={Genes & development},
  year={2005},
  volume={19 12},
  pages={1438-43}
}
The Polycomb group (PcG) gene Bmi1 promotes cell proliferation and stem cell self-renewal by repressing the Ink4a/Arf locus. We used a genetic approach to investigate whether Ink4a or Arf is more critical for relaying Bmi1 function in lymphoid cells, neural progenitors, and neural stem cells. We show that Arf is a general target of Bmi1, however particularly in neural stem cells, derepression of Ink4a contributes to Bmi1(-/-) phenotypes. Additionally, we demonstrate haploinsufficient effects… CONTINUE READING
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