Injury-specific expression of activating transcription factor-3 in retinal ganglion cells and its colocalized expression with phosphorylated c-Jun.

@article{Takeda2000InjuryspecificEO,
  title={Injury-specific expression of activating transcription factor-3 in retinal ganglion cells and its colocalized expression with phosphorylated c-Jun.},
  author={Masumi Takeda and Hitoshi Kato and Akira Takamiya and Akitoshi Yoshida and Hiroshi Kiyama},
  journal={Investigative ophthalmology & visual science},
  year={2000},
  volume={41 9},
  pages={2412-21}
}
PURPOSE To ascribe activating transcription factor (ATF)-3 as a specifically induced transcription factor after ON injury and to describe its putative role as a modulator of c-Jun transactivation. METHODS The adult rat optic nerve was crushed intraorbitally, and expression profiles of ATF-3, ATF-2, and phosphorylated c-Jun (p-c-Jun) were examined by immunohistochemistry and ISH. Western blot analysis for ATF-3 and -2 were also performed. Furthermore, colocalized detection of c-Jun mRNA with… CONTINUE READING

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