Injury of the renal microvascular endothelium alters barrier function after ischemia.

@article{Sutton2003InjuryOT,
  title={Injury of the renal microvascular endothelium alters barrier function after ischemia.},
  author={Timothy A Sutton and Henry E Mang and Silvia Bernardete Campos and Ruben M. Sandoval and Mervin C. Yoder and Bruce A Molitoris},
  journal={American journal of physiology. Renal physiology},
  year={2003},
  volume={285 2},
  pages={F191-8}
}
The role of renal microvascular endothelial cell injury in the pathophysiology of ischemic acute renal failure (ARF) remains largely unknown. No consistent morphological alterations have been ascribed to the endothelium of the renal microvasculature as a result of ischemia-reperfusion injury. Therefore, the purpose of this study was to examine biochemical markers of endothelial injury and morphological changes in the renal microvascular endothelium in a rodent model of ischemic ARF. Circulating… CONTINUE READING