Injury and EGF mediate the expression of alpha6beta4 integrin subunits in corneal epithelium.

@article{Song2001InjuryAE,
  title={Injury and EGF mediate the expression of alpha6beta4 integrin subunits in corneal epithelium.},
  author={Q. H. Song and Rana Krishna Pal Singh and Vickery E Trinkaus-Randall},
  journal={Journal of cellular biochemistry},
  year={2001},
  volume={80 3},
  pages={397-414}
}
Our goal was to evaluate the role of epidermal growth factor and injury on the expression of integrin subunits alpha6(alpha6) and beta4(beta4). An in vitro wound model was used to evaluate corneal wound repair and cellular migration. Primary rabbit corneal epithelial cell cultures were serum-starved and injured in the presence or absence of EGF or tyrphostin AG1478, an inhibitor of EGF receptor kinase activity. Repair was monitored morphologically and expression was analyzed using in situ… CONTINUE READING
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