Injurious mechanical compression of bovine articular cartilage induces chondrocyte apoptosis.

  title={Injurious mechanical compression of bovine articular cartilage induces chondrocyte apoptosis.},
  author={Andreas Markus Loening and Ian E. James and Marc E. Levenston and Alison M. Badger and Eliot H. Frank and Bodo Kurz and Mark E. Nuttall and H H Hung and Simon M. Blake and Alan J. Grodzinsky and Michael W. Lark},
  journal={Archives of biochemistry and biophysics},
  volume={381 2},
  • A. LoeningI. James M. Lark
  • Published 15 September 2000
  • Biology, Engineering
  • Archives of biochemistry and biophysics
A bovine cartilage explant system was used to evaluate the effects of injurious compression on chondrocyte apoptosis and matrix biochemical and biomechanical properties within intact cartilage. Disks of newborn bovine articular cartilage were compressed in vitro to various peak stress levels and chondrocyte apoptotic cell death, tissue biomechanical properties, tissue swelling, glycosaminoglycan loss, and nitrite levels were quantified. Chondrocyte apoptosis occurred at peak stresses as low as… 

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