Injurious mechanical compression of bovine articular cartilage induces chondrocyte apoptosis.

  title={Injurious mechanical compression of bovine articular cartilage induces chondrocyte apoptosis.},
  author={A. Loening and I. E. James and M. Levenston and A. M. Badger and E. Frank and B. Kurz and M. E. Nuttall and H. Hung and S. Blake and A. Grodzinsky and M. Lark},
  journal={Archives of biochemistry and biophysics},
  volume={381 2},
  • A. Loening, I. E. James, +8 authors M. Lark
  • Published 2000
  • Chemistry, Medicine
  • Archives of biochemistry and biophysics
  • A bovine cartilage explant system was used to evaluate the effects of injurious compression on chondrocyte apoptosis and matrix biochemical and biomechanical properties within intact cartilage. Disks of newborn bovine articular cartilage were compressed in vitro to various peak stress levels and chondrocyte apoptotic cell death, tissue biomechanical properties, tissue swelling, glycosaminoglycan loss, and nitrite levels were quantified. Chondrocyte apoptosis occurred at peak stresses as low as… CONTINUE READING
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