Injured primary sensory neurons switch phenotype for brain-derived neurotrophic factor in the rat.

@article{Zhou1999InjuredPS,
  title={Injured primary sensory neurons switch phenotype for brain-derived neurotrophic factor in the rat.},
  author={Xin-fu Zhou and E T Chie and Y S Deng and Jing-lian Zhong and Qing Zhong Xue and Robert Archer Rush and Cory J Xian},
  journal={Neuroscience},
  year={1999},
  volume={92 3},
  pages={841-53}
}
Peripheral nerve injury results in plastic changes in the dorsal root ganglia and spinal cord, and is often complicated with neuropathic pain. The mechanisms underlying these changes are not known. We have now investigated the expression of brain-derived neurotrophic factor in the dorsal root ganglia with histochemical and biochemical methods following sciatic nerve lesion in the rat. The percentage of neurons immunoreactive for brain-derived neurotrophic factor in the ipsilateral dorsal root… CONTINUE READING
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Morphometric analysis and retrograde tracing studies showed that no injured neurons smaller than 600 microm2 were immunoreactive for brain - derived neurotrophic factor , whereas the majority of large injured neurons were immunoreactive in the ipsilateral dorsal root ganglia seven days postlesion .
These studies indicate that sciatic nerve injury results in a differential regulation of brain - derived neurotrophic factor in different subpopulations of sensory neurons in the dorsal root ganglia .
The percentage of neurons immunoreactive for brain - derived neurotrophic factor in the ipsilateral dorsal root ganglia was significantly increased as early as 24 h after the nerve lesion and the increase lasted for at least two weeks .
Both neurons and satellite cells in the lesioned dorsal root ganglia synthesized brain - derived neurotrophic factor messenger RNA after the nerve lesion .
The level of brain - derived neurotrophic factor messenger RNA was also significantly increased in the ipsibut not contralateral dorsal root ganglia .
These studies indicate that sciatic nerve injury results in a differential regulation of brain - derived neurotrophic factor in different subpopulations of sensory neurons in the dorsal root ganglia .
The level of brain - derived neurotrophic factor messenger RNA was also significantly increased in the ipsibut not contralateral dorsal root ganglia .
Morphometric analysis and retrograde tracing studies showed that no injured neurons smaller than 600 microm2 were immunoreactive for brain - derived neurotrophic factor , whereas the majority of large injured neurons were immunoreactive in the ipsilateral dorsal root ganglia seven days postlesion .
Both neurons and satellite cells in the lesioned dorsal root ganglia synthesized brain - derived neurotrophic factor messenger RNA after the nerve lesion .
The percentage of neurons immunoreactive for brain - derived neurotrophic factor in the ipsilateral dorsal root ganglia was significantly increased as early as 24 h after the nerve lesion and the increase lasted for at least two weeks .
These studies indicate that sciatic nerve injury results in a differential regulation of brain - derived neurotrophic factor in different subpopulations of sensory neurons in the dorsal root ganglia .
The level of brain - derived neurotrophic factor messenger RNA was also significantly increased in the ipsibut not contralateral dorsal root ganglia .
Morphometric analysis and retrograde tracing studies showed that no injured neurons smaller than 600 microm2 were immunoreactive for brain - derived neurotrophic factor , whereas the majority of large injured neurons were immunoreactive in the ipsilateral dorsal root ganglia seven days postlesion .
Both neurons and satellite cells in the lesioned dorsal root ganglia synthesized brain - derived neurotrophic factor messenger RNA after the nerve lesion .
The percentage of neurons immunoreactive for brain - derived neurotrophic factor in the ipsilateral dorsal root ganglia was significantly increased as early as 24 h after the nerve lesion and the increase lasted for at least two weeks .
The brain - derived neurotrophic factor - immunoreactive nerve terminals in the ipsilateral spinal cord were reduced in the central region of lamina II , but increased in more medial regions or deeper into laminae III / IV .
Peripheral nerve injury results in plastic changes in the dorsal root ganglia and spinal cord , and is often complicated with neuropathic pain .
Peripheral nerve injury results in plastic changes in the dorsal root ganglia and spinal cord , and is often complicated with neuropathic pain .
The brain - derived neurotrophic factor - immunoreactive nerve terminals in the ipsilateral spinal cord were reduced in the central region of lamina II , but increased in more medial regions or deeper into laminae III / IV .
Peripheral nerve injury results in plastic changes in the dorsal root ganglia and spinal cord , and is often complicated with neuropathic pain .
Peripheral nerve injury results in plastic changes in the dorsal root ganglia and spinal cord , and is often complicated with neuropathic pain .
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