Injection of vascular endothelial growth factor into knee joints induces osteoarthritis in mice.

  title={Injection of vascular endothelial growth factor into knee joints induces osteoarthritis in mice.},
  author={Aya Ludin and Jona J. Sela and Agnes Schroeder and Yuval Samuni and Dorrit W. Nitzan and Gail Amir},
  journal={Osteoarthritis and cartilage},
  volume={21 3},
UNLABELLED Osteoarthritis (OA) is a common joint disorder affecting circa 2% of the population. OBJECTIVES It has been suggested that secretion of vascular endothelial growth factor (VEGF) could play a role in the chain of events leading to OA. METHODS In the present study, healthy mice were injected intra-articularly with VEGF. RESULTS Shortly after the administration of VEGF, synovial hyperplasia, increased calcification of the articular cartilage and bone sclerosis were observed… CONTINUE READING
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