Injection of hypertonic saline or mannitol accelerates the dehydration-induced activation of dopamine synthesis in the neurointermediate lobe of the rat hypophysis.

@article{Alper1982InjectionOH,
  title={Injection of hypertonic saline or mannitol accelerates the dehydration-induced activation of dopamine synthesis in the neurointermediate lobe of the rat hypophysis.},
  author={Richard H. Alper and Kenneth E. Moore},
  journal={Neuroendocrinology},
  year={1982},
  volume={35 6},
  pages={
          469-74
        }
}
The rate of dopamine (DA) synthesis (DOPA accumulation after the administration of an inhibitor of aromatic L-amino acid decarboxylase) was determined in terminals of tuberohypophyseal DA neurons in the neurointermediate lobe (NIL) of the rat hypophysis at various times after the presentation of osmotic stimuli. DA synthesis in the NIL, but not in median eminence or striatum, was increased 24 h but not 4 h after an injection of hypertonic saline (5 ml 15% NaCl/kg, s.c.), provided the animals… CONTINUE READING