Injection of colchicine intra-hippocampal cortical area 1 enhances novelty seeking behavior

@inproceedings{Karami2013InjectionOC,
  title={Injection of colchicine intra-hippocampal cortical area 1 enhances novelty seeking behavior},
  author={Manizheh Karami and Nosaibeh Riahi and Mohammad Reza Jalali Nadoushan},
  booktitle={Indian journal of pharmacology},
  year={2013}
}
OBJECTIVE Colchicine, a potent neurotoxin derived of plant has been recently identified as a degenerative toxin of small pyramidal cells in the hippocampal cortical area 1 (CA1). In this study, the effect of the alkaloid intra hippocampal CA1 on the novelty seeking behavior in the conditioning task was measured. MATERIALS AND METHODS Injections of colchicine (1-75 μg/rat, intra-CA1) were performed in cannulated male Wistar rats while being settled in the stereotaxic apparatus. Control group… CONTINUE READING
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