Injection of adult neurospheres induces recovery in a chronic model of multiple sclerosis

@article{Pluchino2003InjectionOA,
  title={Injection of adult neurospheres induces recovery in a chronic model of multiple sclerosis},
  author={Stefano Pluchino and Angelo Quattrini and Elena Brambilla and Angela Pesenti Gritti and Giuliana Salani and Giorgia Dina and R Galli and Ubaldo Del Carro and Stefano Amadio and Alessandra Bergami and Roberto Furlan and Giancarlo Comi and Angelo L. Vescovi and Gianvito Martino},
  journal={Nature},
  year={2003},
  volume={422},
  pages={688-694}
}
Widespread demyelination and axonal loss are the pathological hallmarks of multiple sclerosis. The multifocal nature of this chronic inflammatory disease of the central nervous system complicates cellular therapy and puts emphasis on both the donor cell origin and the route of cell transplantation. We established syngenic adult neural stem cell cultures and injected them into an animal model of multiple sclerosis—experimental autoimmune encephalomyelitis (EAE) in the mouse—either intravenously… CONTINUE READING
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