Injection of a recombinant AAV serotype 2 into canine skeletal muscles evokes strong immune responses against transgene products

@article{Yuasa2007InjectionOA,
  title={Injection of a recombinant AAV serotype 2 into canine skeletal muscles evokes strong immune responses against transgene products},
  author={Katsutoshi Yuasa and Mayuko Yoshimura and Nobuyuki Urasawa and Sachiko Ohshima and Joseph M Howell and Atsushi Nakamura and Takao Hijikata and Yuko Miyagoe-Suzuki and Shin’ichi Takeda},
  journal={Gene Therapy},
  year={2007},
  volume={14},
  pages={1249-1260}
}
Using murine models, we have previously demonstrated that recombinant adeno-associated virus (rAAV)-mediated microdystrophin gene transfer is a promising approach to treatment of Duchenne muscular dystrophy (DMD). To examine further therapeutic effects and the safety issue of rAAV-mediated microdystrophin gene transfer using larger animal models, such as dystrophic dog models, we first investigated transduction efficiency of rAAV in wild-type canine muscle cells, and found that rAAV2 encoding… CONTINUE READING
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