Injection of Phosphatidylcholine in Fat Tissue: Experimental Study of Local Action in Rabbits

@article{Rittes2005InjectionOP,
  title={Injection of Phosphatidylcholine in Fat Tissue: Experimental Study of Local Action in Rabbits},
  author={Patr{\'i}cia Guedes Rittes and Jos{\'e} Carlos Rittes and Maria Fernanda Carriel Amary},
  journal={Aesthetic Plastic Surgery},
  year={2005},
  volume={30},
  pages={474-478}
}
BackgroundsSubcutaneous phosphatidylcholine to cause local lipolysis has been performed effectively and safely in the nonsurgical treatment of periorbital fat pads and also in the treatment of localized fat deposits in the abdomen, neck, arms and thighs. However, the studies do not explain the mechanism through which injectable phosphatidylcholine causes localized fat reduction. This study aimed to compare the local action of a phosphatidylcholine formulation with that of a physiologic saline… 
The Effect of Phosphatidylcholine and Deoxycholate Compound Injections to the Localized Adipose Tissue: An Experimental Study with a Murine Model
TLDR
The efficacy of the PPC dissolved in DCA via an experimental rat study model is discussed, along with suggesting a useful animal experimental model for the study of adipose tissue and lipolysis and recommending the rat inguinal fat pad model, as it is likely to be useful in related research.
Tissue‐Toxic Effects of Phosphatidylcholine/Deoxycholate after Subcutaneous Injection for Fat Dissolution in Rats and a Human Volunteer
TLDR
Injection lipolysis with PC/DC causes tissue fibrosis and necrosis of adipose and vascular tissues in rat and man, making the long-term safety of PC/ DC for nonsurgical treatment of subcutaneous fat deposits uncertain.
Phosphatidylcholine and Sodium Deoxycholate in the Treatment of Localized Fat: A Double‐Blind, Randomized Study
TLDR
Both treatments have shown moderate and equivalent efficacy in treating localized fat, with sodium deoxycholate having a slower postoperative resolution, suggesting that sodium de oxygencholate could be sufficient by itself to determine fat cell destruction and that phosphatidylcholine could be useful for obtaining a later emulsification of the fat.
Histological changes after treatment for localized fat deposits with phosphatidylcholine and sodium deoxycholate
TLDR
Important microscopic evidence of substitution of fat by fibrosis, marked inflammatory infiltration with microabscess formation in the dermis, and septal and lobular panniculitis with thick fibrous septa is observed in the subcutaneous fat following PPC and DC injections.
Evaluation of Safe and Effectiveness of an Injectable Solution Acid Deoxycholic Based for Reduction of Localized Adiposities
TLDR
Studies have shown that the second-generation solution containing sodium deoxycholate 1.25% is effective and safe to treat different localized fat deposits and was not associated with a lesser degree of handling.
A New Method to Quantify the Effect After Subcutaneous Injection of Lipolytic Substances
TLDR
The data suggest that RT-3D ultrasound imaging could be a simple and fast method for proving the effects on volume size after lipolytic procedures, and orciprenalin (Alupent®) showed the highestlipolytic effect in the authors' animal model.
Compounds Used for ‘Injection Lipolysis’ Destroy Adipocytes and other Cells Found in Adipose Tissue
TLDR
Applying injection lipolysis with phosphatidylcholine as the major injected compound reduces subcutaneous fat pad size through cell and tissue destruction represents off-label drug use and application of a drug by a contraindicated route.
Refinement of technique in injection lipolysis based on scientific studies and clinical evaluation.
The Role of Fat Reducing Agents on Adipocyte Death and Adipose Tissue Inflammation
TLDR
A PubMed search and review of articles integrated the findings of this growing body of literature into a proposed mechanism of fat reduction and provides direction for further studies.
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