Injection of PEGylated liposomes in rats elicits PEG-specific IgM, which is responsible for rapid elimination of a second dose of PEGylated liposomes.

@article{Ishida2006InjectionOP,
  title={Injection of PEGylated liposomes in rats elicits PEG-specific IgM, which is responsible for rapid elimination of a second dose of PEGylated liposomes.},
  author={Tatsuhiro Ishida and Masako Ichihara and Xinyu Wang and Kenji Yamamoto and Junji Kimura and Eiji Majima and Hiroshi Kiwada},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2006},
  volume={112 1},
  pages={
          15-25
        }
}
  • T. Ishida, M. Ichihara, H. Kiwada
  • Published 1 May 2006
  • Biology, Chemistry
  • Journal of controlled release : official journal of the Controlled Release Society
Anti-PEG IgM elicited by injection of liposomes is involved in the enhanced blood clearance of a subsequent dose of PEGylated liposomes.
Spleen plays an important role in the induction of accelerated blood clearance of PEGylated liposomes.
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Factors affecting the accelerated blood clearance of polyethylene glycol-liposomes upon repeated injection.
TLDR
The results indicate that hepatosplenic macrophages play an essential role in the enhanced clearance effect and that the change in pharmacokinetic behavior upon repeated injection is a general characteristic of liposomes, unrelated to the presence of PEG.
In vivo applications of PEG liposomes: unexpected observations.
TLDR
It is considered that PEG liposomes are not inert drug-carrying vehicles in vivo, and pharmacological effects can occur, induced solely by using liposomal particles irrespective of the drug content.
The accelerated clearance on repeated injection of pegylated liposomes in rats: laboratory and histopathological study.
TLDR
The results suggest that the multiple injection of the PEGylated liposomes do not give animal body a strong stimulation and have a considerable impact in and important implications on the clinical application, design and engineering of P EGylatedliposomes for repeated intravenous administration.
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