Injection of PEGylated liposomes in rats elicits PEG-specific IgM, which is responsible for rapid elimination of a second dose of PEGylated liposomes.

@article{Ishida2006InjectionOP,
  title={Injection of PEGylated liposomes in rats elicits PEG-specific IgM, which is responsible for rapid elimination of a second dose of PEGylated liposomes.},
  author={Tatsuhiro Ishida and Masako Ichihara and Xinyu Wang and Kenji Yamamoto and Junji Kimura and Eiji Majima and Hiroshi Kiwada},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2006},
  volume={112 1},
  pages={
          15-25
        }
}
  • T. Ishida, M. Ichihara, H. Kiwada
  • Published 1 May 2006
  • Biology, Chemistry
  • Journal of controlled release : official journal of the Controlled Release Society
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Anti-PEG IgM elicited by injection of liposomes is involved in the enhanced blood clearance of a subsequent dose of PEGylated liposomes.
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Accelerated blood clearance (ABC) phenomenon upon repeated injection of PEGylated liposomes.
Effects of cleavable PEG-cholesterol derivatives on the accelerated blood clearance of PEGylated liposomes.
T cell-independent B cell response is responsible for ABC phenomenon induced by repeated injection of PEGylated liposomes.
Transport of PEGylated liposomes from the splenic marginal zone to the follicle in the induction phase of the accelerated blood clearance phenomenon.
Use of polyglycerol (PG), instead of polyethylene glycol (PEG), prevents induction of the accelerated blood clearance phenomenon against long-circulating liposomes upon repeated administration.
The contribution of phagocytic activity of liver macrophages to the accelerated blood clearance (ABC) phenomenon of PEGylated liposomes in rats.
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References

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Effect of the physicochemical properties of initially injected liposomes on the clearance of subsequently injected PEGylated liposomes in mice.
Accelerated clearance of a second injection of PEGylated liposomes in mice.
Influence of the physicochemical properties of liposomes on the accelerated blood clearance phenomenon in rats.
Factors affecting the accelerated blood clearance of polyethylene glycol-liposomes upon repeated injection.
TLDR
The results indicate that hepatosplenic macrophages play an essential role in the enhanced clearance effect and that the change in pharmacokinetic behavior upon repeated injection is a general characteristic of liposomes, unrelated to the presence of PEG.
In vivo applications of PEG liposomes: unexpected observations.
TLDR
It is considered that PEG liposomes are not inert drug-carrying vehicles in vivo, and pharmacological effects can occur, induced solely by using liposomal particles irrespective of the drug content.
The accelerated clearance on repeated injection of pegylated liposomes in rats: laboratory and histopathological study.
TLDR
The results suggest that the multiple injection of the PEGylated liposomes do not give animal body a strong stimulation and have a considerable impact in and important implications on the clinical application, design and engineering of P EGylatedliposomes for repeated intravenous administration.
Sterically stabilized liposomes: a hypothesis on the molecular origin of the extended circulation times.
Association of blood proteins with large unilamellar liposomes in vivo. Relation to circulation lifetimes.
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