Injection of Mesobuthus tamulus venom in distal segment of femoral artery evokes hyperventilatory and hypertensive responses in anaesthetised rats

@article{Singh2008InjectionOM,
  title={Injection of Mesobuthus tamulus venom in distal segment of femoral artery evokes hyperventilatory and hypertensive responses in anaesthetised rats},
  author={Sanjeev K. Singh and Shripad Bhimarao Deshpande},
  journal={Neuroscience Letters},
  year={2008},
  volume={438},
  pages={64-66}
}
Intra-arterial (i.a.) injection of Indian red scorpion (Mesobuthus tamulus; BT) venom produces cardiorespiratory changes by involving perivascular receptors. The afferents involved in mediating these reflex responses are not known. The present investigation was conducted to examine the afferents mediating the vasosensory reflexes evoked by i.a. injection of BT venom in the peripheral end of femoral artery in urethane anaesthetised rats. Blood pressure (BP), ECG (for heart rate), and respiratory… 
10 Citations
B1-kinin receptors modulate Mesobuthus tamulus venom-induced vasosensory reflex responses in anesthetized rats
TLDR
BT venom-induced vasosensory reflex responses modulating cardiovascular parameters are mediated via B1-kinin receptors in anesthetized rats via kinin receptors.
Buthus tamulus venom-induced vasosensory reflexes are mediated through efferent pathways in sympathetic and vagal parasympathetics
TLDR
The findings suggest that the venom-induced vasosensory responses involve alpha(1)-adrenoceptors for BP and vagal efferents for HR changes in terazosin pretreated animals.
Vasosensory reflex responses are mediated through the afferents originating from vascular plexuses in anaesthetised rats
TLDR
In the neurotomised animals, venom-induced mean arterial pressure and respiratory rate changes were markedly attenuated but not the heart rate changes indicating the existence of additional afferent pathway, and evidence for afferent pathways in somatic nerves and also through the perivascular nerve plexuses is provided.
Instillation of bradykinin into femoral artery elicits cardiorespiratory reflexes involving perivascular afferents in anesthetized rats.
TLDR
A novel study exhibiting the role of peripheral blood vessels in the regulation of the cardiorespiratory system by stimulating the perivascular nociceptors involving prostaglandins in urethane-anesthetized male rats.
Nociceptive vascular reflexes evoked by scorpion venom modulate cardiorespiratory parameters involving vanilloid receptor 1 in anaesthetised rats
TLDR
The observations indicate that the cardiorespiratory changes induced by intra-arterial injection of venom are carried by afferents in addition to somatic nerves, involving mainly VR1 receptors and partially by 5-HT(3) receptors.
Vasosensory responses elicited by Indian red scorpion venom last longer than capsaicin-induced responses.
TLDR
It is suggested that intraarterial injection of BT venom produces prolonged cardiorespiratory alterations as compared to the capsaicin-induced responses.
Intra-arterial injection of bradykinin produces reflex cardiorespiratory changes involving histamine receptors in anesthetized rats
TLDR
The data provide evidences for the involvement of H1 and H2 receptors in producing the BK-induced vasosensory reflex responses modulating the cardiovascular parameters in anesthetized rats.
Ipsilateral somatic nerves mediate histamine-induced vasosensory reflex responses involving perivascular afferents in rat models
TLDR
It is concluded that instillation of 10 mM of histamine produces optimal vasosensory reflex responses originating from the local vascular bed; afferents and efferents of which are mostly located in ipsilateral somatic and vagus nerves respectively.
Perivascular histamine receptors mediate vasosensory reflex responses elicited by thermal nociceptive stimuli in anaesthetised rat models
Reflex responses elicited by intra-arterial (i.a) instillation of nociceptive agents are known as vasosensory reflex responses. The present study was designed to demonstrate the vasosensory reflex
Retrograde cannulation of femoral artery: A novel experimental design for precise elicitation of vasosensory reflexes in anesthetized rats
TLDR
A novel method for the stimulation of perivascular afferents was designed by retrograde cannulation of femoral artery, using a 24G, double ported polyethylene cannula, which substantiates the proposition regarding minimal systemic spillage.

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