Injection of Mesobuthus tamulus venom in distal segment of femoral artery evokes hyperventilatory and hypertensive responses in anaesthetised rats

  title={Injection of Mesobuthus tamulus venom in distal segment of femoral artery evokes hyperventilatory and hypertensive responses in anaesthetised rats},
  author={Sanjeev K. Singh and Shripad Bhimarao Deshpande},
  journal={Neuroscience Letters},
10 Citations
B1-kinin receptors modulate Mesobuthus tamulus venom-induced vasosensory reflex responses in anesthetized rats
BT venom-induced vasosensory reflex responses modulating cardiovascular parameters are mediated via B1-kinin receptors in anesthetized rats via kinin receptors.
Vasosensory reflex responses are mediated through the afferents originating from vascular plexuses in anaesthetised rats
In the neurotomised animals, venom-induced mean arterial pressure and respiratory rate changes were markedly attenuated but not the heart rate changes indicating the existence of additional afferent pathway, and evidence for afferent pathways in somatic nerves and also through the perivascular nerve plexuses is provided.
Instillation of bradykinin into femoral artery elicits cardiorespiratory reflexes involving perivascular afferents in anesthetized rats.
A novel study exhibiting the role of peripheral blood vessels in the regulation of the cardiorespiratory system by stimulating the perivascular nociceptors involving prostaglandins in urethane-anesthetized male rats.
Vasosensory responses elicited by Indian red scorpion venom last longer than capsaicin-induced responses.
It is suggested that intraarterial injection of BT venom produces prolonged cardiorespiratory alterations as compared to the capsaicin-induced responses.
Intra-arterial injection of bradykinin produces reflex cardiorespiratory changes involving histamine receptors in anesthetized rats
The data provide evidences for the involvement of H1 and H2 receptors in producing the BK-induced vasosensory reflex responses modulating the cardiovascular parameters in anesthetized rats.
Ipsilateral somatic nerves mediate histamine-induced vasosensory reflex responses involving perivascular afferents in rat models
It is concluded that instillation of 10 mM of histamine produces optimal vasosensory reflex responses originating from the local vascular bed; afferents and efferents of which are mostly located in ipsilateral somatic and vagus nerves respectively.
Perivascular histamine receptors mediate vasosensory reflex responses elicited by thermal nociceptive stimuli in anaesthetised rat models
The present study was designed to demonstrate the vasosensory reflex responses evoked by thermal nociceptive stimuli in anaesthetised rat models and to examine the role of perivascular histamine receptors in mediating these responses.


Intra-arterial injection of Mesobuthus tamulus venom elicits cardiorespiratory reflexes involving perivascular afferents.
Pulmonary oedema produced by scorpion venom augments a phenyldiguanide‐induced reflex response in anaesthetized rats
The results of this study indicate that the venom‐induced augmentation of the PDG reflex is associated with pulmonary oedema involving kinins utilizing 5‐HT3 receptors.
Anandamide induces cardiovascular and respiratory reflexes via vasosensory nerves in the anaesthetized rat
It is demonstrated that both the endogenous cannabinoid, anandamide, and the vanilloid, capsaicin, evoke CVR reflexes when injected intra‐arterially into the rat hindlimb.
Protective effects of aprotinin on respiratory and cardiac abnormalities induced by Mesobuthus tamulus venom in adult rats.
  • R. Pandey, S. Deshpande
  • Biology, Medicine
    Toxicon : official journal of the International Society on Toxinology
  • 2004
Insulin reverses haemodynamic changes and pulmonary oedema in children stung by the Indian red scorpion Mesobuthus tamulus concanesis, Pocock.
It is concluded that insulin administration may be useful in reversing haemodynamic changes and pulmonary oedema in victims of scorpion stings.
Activation of P2X receptors for adenosine triphosphate evokes cardiorespiratory reflexes in anaesthetized rats
The hypothesis that P2X receptor subtypes for ATP are associated with specific sensory nerves that form part of the homeostatic mechanism for cardiovascular and respiratory regulation and these receptors therefore have physiological, pathological and therapeutic significance is supported.
On the management of scorpion stings
The results with experimental animals have shown two stages of envenomation—namely, a stage of immediate respiratory failure and a delayed stage of circulatory failure, which appears to be mediated by the neuronal components.
Basic mechanisms in vascular headache.