Injection of L-allylglycine into the posterior hypothalamus in rats causes decreases in local gaba which correlate with increases in heart rate

@article{Abshire1988InjectionOL,
  title={Injection of L-allylglycine into the posterior hypothalamus in rats causes decreases in local gaba which correlate with increases in heart rate},
  author={V. M. Abshire and K. Hankins and K. E. Roehr and J. Dimicco},
  journal={Neuropharmacology},
  year={1988},
  volume={27},
  pages={1171-1177}
}
  • V. M. Abshire, K. Hankins, +1 author J. Dimicco
  • Published 1988
  • Biology, Medicine
  • Neuropharmacology
  • Injection of the GABA antagonist, bicuculline methiodide into the posterior hypothalamus of rats has been shown to cause marked increases in heart rate and lesser elevations in blood pressure. Allylglycine is a potent inhibitor of the synthetic enzyme for GABA, glutamic acid decarboxylase, only after in vivo biotransformation into its active form, 2-keto-4-pentenoic acid, through a stereospecific amino acid oxidase. The posterior hypothalamus is thought to contain substantial activity only of L… CONTINUE READING
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