Injection of Aβ1-40 into hippocampus induced cognitive lesion associated with neuronal apoptosis and multiple gene expressions in the tree shrew

@article{Lin2016InjectionOA,
  title={Injection of Aβ1-40 into hippocampus induced cognitive lesion associated with neuronal apoptosis and multiple gene expressions in the tree shrew},
  author={Na Lin and Liu-lin Xiong and Rongping Zhang and Hong Zheng and Lei Wang and Zhong-yi Qian and Piao Zhang and Zhi-Wei Chen and Fabao Gao and Ting-Hua Wang},
  journal={Apoptosis},
  year={2016},
  volume={21},
  pages={621-640}
}
Alzheimer’s disease (AD) can incur significant health care costs to the patient, their families, and society; furthermore, effective treatments are limited, as the mechanisms of AD are not fully understood. This study utilized twelve adult male tree shrews (TS), which were randomly divided into PBS and amyloidbetapeptide1-40 (Aβ1-40) groups. AD model was established via an intracerebroventricular (icv) injection of Aβ1-40 after being incubated for 4 days at 37 °C. Behavioral, pathophysiological… CONTINUE READING
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