Injected nanoparticles: the combination of experimental systems to assess cardiovascular adverse effects.

@article{Vlasova2014InjectedNT,
  title={Injected nanoparticles: the combination of experimental systems to assess cardiovascular adverse effects.},
  author={Maria A Vlasova and Olga S. Tarasova and Joakim Riikonen and Janne Raula and Anatoly S. Lobach and Anna A. Borzykh and Boris V Smirin and Esko I. Kauppinen and Alexander V. Eletskii and Karl-Heinz Herzig and Jarno J Salonen and Pasi Tavi and Vesa-Pekka Lehto and K. J{\"a}rvinen},
  journal={European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V},
  year={2014},
  volume={87 1},
  pages={64-72}
}
When nanocarriers are used for drug delivery they can often achieve superior therapeutic outcomes over standard drug formulations. However, concerns about their adverse effects are growing due to the association between exposure to certain nanosized particles and cardiovascular events. Here we examine the impact of intravenously injected drug-free nanocarriers on the cardiovasculature at both the systemic and organ levels. We combine in vivo and in vitro methods to enable monitoring of… CONTINUE READING

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