Injectable collagenase clostridium histolyticum for Dupuytren's contracture.

@article{Hurst2009InjectableCC,
  title={Injectable collagenase clostridium histolyticum for Dupuytren's contracture.},
  author={L. Hurst and M. Badalamente and V. Hentz and R. Hotchkiss and F. Kaplan and R. Meals and T. Smith and J. Rodzvilla},
  journal={The New England journal of medicine},
  year={2009},
  volume={361 10},
  pages={
          968-79
        }
}
BACKGROUND Dupuytren's disease limits hand function, diminishes the quality of life, and may ultimately disable the hand. Surgery followed by hand therapy is standard treatment, but it is associated with serious potential complications. Injection of collagenase clostridium histolyticum, an office-based, nonsurgical option, may reduce joint contractures caused by Dupuytren's disease. METHODS We enrolled 308 patients with joint contractures of 20 degrees or more in this prospective, randomized… Expand
562 Citations

Paper Mentions

Interventional Clinical Trial
Dupuytren's disease is a non-curative, progressive disorder leading to function-impairing deformities of the hand. Although numerous treatments exist, the most common and widely… Expand
ConditionsDupuytren Contracture, Dupuytren's Disease of Finger
InterventionDrug, Procedure
Interventional Clinical Trial
Dupuytren's disease results in deformity of the hand and this can lead to trouble with daily activities. Treatment traditionally involves cutting out diseased tissue, however this can… Expand
ConditionsDupuytren Contracture
InterventionDrug, Procedure
Interventional Clinical Trial
This study will evaluate the efficacy and safety of clostridial collagenase injections for treatment of Dupuytren's contracture of the thumb and first web space. The investigators… Expand
ConditionsDupuytren's Contracture
InterventionBiological
Interventional Clinical Trial
The purpose of this study is to determine if of manipulation of digits following collagenase injection for treatment of Dupuytren's contracture is effected by the amount of time between… Expand
ConditionsDupuytren's Disease
InterventionBiological
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References

SHOWING 1-10 OF 33 REFERENCES
Enzyme injection as nonsurgical treatment of Dupuytren's disease.
  • 137
  • PDF
Collagenase in the treatment of Dupuytren's disease: an in vitro study.
  • 109
  • PDF
Percutaneous Needle Aponeurotomy: Complications and Results✩
  • 177
Results of Partial Fasciectomy for Dupuytren Disease in 261 Consecutive Patients
  • 101
  • PDF
Cigarette smoking and Dupuytren's contracture of the hand.
  • 70
Nonoperative treatment of Dupuytren's disease.
  • 40
The complications of Dupuytren's contracture surgery.
  • 125
  • PDF
...
1
2
3
4
...