Injectable MMP-sensitive alginate hydrogels as hMSC delivery systems.

@article{Fonseca2014InjectableMA,
  title={Injectable MMP-sensitive alginate hydrogels as hMSC delivery systems.},
  author={Keila B. Fonseca and David B. Gomes and Kangwon Lee and Susana Gomes Santos and Aureliana Sousa and Eduardo A Silva and David J Mooney and Pedro L Granja and Cristina C. Barrias},
  journal={Biomacromolecules},
  year={2014},
  volume={15 1},
  pages={
          380-90
        }
}
Hydrogels with the potential to provide minimally invasive cell delivery represent a powerful tool for tissue-regeneration therapies. In this context, entrapped cells should be able to escape the matrix becoming more available to actively participate in the healing process. Here, we analyzed the performance of proteolytically degradable alginate hydrogels as vehicles for human mesenchymal stem cells (hMSC) transplantation. Alginate was modified with the matrix metalloproteinase (MMP)-sensitive… CONTINUE READING

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