Injectable Hyaluronan Hydrogels with Peptide-Binding Dendrimers Modulate the Controlled Release of BMP-2 and TGF-β1.

@article{Seelbach2015InjectableHH,
  title={Injectable Hyaluronan Hydrogels with Peptide-Binding Dendrimers Modulate the Controlled Release of BMP-2 and TGF-β1.},
  author={Ryan J Seelbach and Peter Fransen and Daniel Pulido and Matteo D’Este and Fabian Duttenhoefer and Sebastian Sauerbier and Thomas M. Freiman and Philipp Niemeyer and Fernando Albericio and Mauro Alini and Miriam Royo and Alvaro Mata and David Eglin},
  journal={Macromolecular bioscience},
  year={2015},
  volume={15 8},
  pages={
          1035-44
        }
}
BMP-2 and TGF-β1 released from injectable thermoresponsive hydrogels are studied in the presence and absence of branched macromolecules bearing BMP-2 or TGF-β1 affinity binding peptides. The synthesized branched macromolecules and the gelling compositions before and after loading with either BMP-2 or TGF-β1 are characterized physico-chemically and show a significantly lower amount of proteins released in the presence of the affinity binding peptide macromolecules. This study illustrates the… CONTINUE READING

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