Initiator-elongator discrimination in vertebrate tRNAs for protein synthesis.

@article{Drabkin1998InitiatorelongatorDI,
  title={Initiator-elongator discrimination in vertebrate tRNAs for protein synthesis.},
  author={Harold J. Drabkin and Melanie Estrella and Uttam L. RajBhandary},
  journal={Molecular and cellular biology},
  year={1998},
  volume={18 3},
  pages={1459-66}
}
Initiator tRNAs are used exclusively for initiation of protein synthesis and not for the elongation step. We show, in vivo and in vitro, that the primary sequence feature that prevents the human initiator tRNA from acting in the elongation step is the nature of base pairs 50:64 and 51:63 in the TpsiC stem of the initiator tRNA. Various considerations suggest that this is due to sequence-dependent perturbation of the sugar phosphate backbone in the TpsiC stem of initiator tRNA, which most likely… CONTINUE READING

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