Initiation signals for complementary strand DNA synthesis in the region of the replication origin of the Escherichia coli chromosome.

@article{Stuitje1984InitiationSF,
  title={Initiation signals for complementary strand DNA synthesis in the region of the replication origin of the Escherichia coli chromosome.},
  author={A. R. Stuitje and Peter Weisbeek and Michiel Meijer},
  journal={Nucleic acids research},
  year={1984},
  volume={12 7},
  pages={3321-32}
}
We have used an in vivo plasmid-phi X174 packaging system to detect replication initiation signals in the region of the replication origin (oriC) of the Escherichia coli chromosome. The results obtained are summarized as follows: (i) Neither within nor close to oriC effective signals for initiating complementary strand synthesis could be detected. We conclude that initiation mechanisms for leading and lagging strand synthesis at oriC are not identical to any known priming mechanism of DNA… CONTINUE READING

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