Initiation protein induced helix destabilization at the lambda origin: a prepriming step in DNA replication.

Abstract

The interaction of the lambda phage initiator protein, O, with the lambda origin sequence, ori, has been investigated. Binding of O, or its amino-terminal fragment, causes a major structural change within a 60 bp AT-rich region just to the right of the O-binding site. ATP or other molecular energy sources are not required. The modification, as assayed by… (More)

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Cite this paper

@article{Schnos1988InitiationPI, title={Initiation protein induced helix destabilization at the lambda origin: a prepriming step in DNA replication.}, author={M Schnos and Ken Zahn and Ross B. Inman and Fredrick R Blattner}, journal={Cell}, year={1988}, volume={52 3}, pages={385-95} }