Initiation on the divergent Type I cadicivirus IRES: factor requirements and interactions with the translation apparatus

@inproceedings{Asnani2016InitiationOT,
  title={Initiation on the divergent Type I cadicivirus IRES: factor requirements and interactions with the translation apparatus},
  author={Mukta Asnani and Tatyana V. Pestova and Christopher U. T. Hellen},
  booktitle={Nucleic acids research},
  year={2016}
}
Cadicivirus (CDV) is unique amongst picornaviruses in having a dicistronic genome with internal ribosomal entry sites (IRESs) preceding both open reading frames. Here, we investigated initiation on the 5'-terminal IRES. We report that the 982-nt long 5'UTR comprises 12 domains (d1-d12), five of which (d8-d12, nts 341-950) constitute a divergent Type I IRES. It comprises central elements (the apex of d10, d11 and the following polypyrimidine tract) that are homologous to corresponding elements… CONTINUE READING
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