Initiation of vertebrate left–right axis formation by maternal Vg1

  title={Initiation of vertebrate left–right axis formation by maternal Vg1},
  author={Brian A. Hyatt and Jamie L. Lohr and H Joseph Yost},
IN the development of the three-dimensional vertebrate body plan, the left–right axis is linked to the dorsoventral and anterioposterior axes1,2. In humans, altered left–right development results in severe cardiovascular and visceral abnormalities in individuals and in conjoined twins3,4. Although zygotically tran-scribed genes that are asymmetrically expressed have been identified5–8, the mechanism by which left–right asymmetries are established during embryogenesis is unknown9. Here we show… CONTINUE READING
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