Initiation of urinary bladder carcinogenesis in rats by freeze ulceration with sodium saccharin promotion.

Abstract

Sodium saccharin was previously shown to induce a significant incidence of transitional cell carcinoma of the bladder when administered to rats either immediately or beginning 2 weeks after ulceration of the bladder epithelium induced by freezing or cyclophosphamide injection. However, the marked regenerative hyperplasia following ulceration by either of… (More)

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