Initiation of tumor necrosis factor α antagonists and risk of fractures in patients with selected rheumatic and autoimmune diseases.

@article{Kawai2013InitiationOT,
  title={Initiation of tumor necrosis factor α antagonists and risk of fractures in patients with selected rheumatic and autoimmune diseases.},
  author={V K Kawai and Carlos Gabriel Grijalva and Patrick G. Arbogast and Jeffrey R. Curtis and Daniel H. Solomon and Elizabeth S. Delzell and Lang G Chen and Rita P Ouellet-Hellstrom and Lisa J Herrinton and Liyan Liu and Edward F Mitchell and Charles M. Stein and Marie R. Griffin},
  journal={Arthritis care & research},
  year={2013},
  volume={65 7},
  pages={1085-94}
}
OBJECTIVE We tested the hypothesis that initiation of tumor necrosis factor α (TNFα) antagonists reduced the risk of fractures compared to nonbiologic comparators in patients with autoimmune diseases. METHODS Using 4 large administrative databases, we assembled retrospective cohorts of patients with autoimmune diseases who initiated either a TNFα antagonist or a nonbiologic medication. We identified 3 mutually exclusive disease groups: rheumatoid arthritis (RA), inflammatory bowel disease… CONTINUE READING
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