Initiation of translation makes attenuation of ampC in E. coli dependent on growth rate

  title={Initiation of translation makes attenuation of ampC in E. coli dependent on growth rate},
  author={Thomas Grundstr{\"o}m and Staffan J. Normark},
  journal={Molecular and General Genetics MGG},
The chromosomal β-lactamase gene of E. coli, ampC, shows increased expression with increased growth rate of the bacteria. We have previously shown that transcription of ampC is attenuated, and that a mutation in the terminator stem of this attenuator abolishes the growth rate-dependency of ampC expression. We now present studies using mutations, made in vitro, located such that the 5′-end of ampC mRNA carries a possible recognition sequence for initiation of translation close to the attenuator… CONTINUE READING


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