Initiation of the yeast G0 program requires Igo1 and Igo2, which antagonize activation of decapping of specific nutrient-regulated mRNAs.

@article{Luo2011InitiationOT,
  title={Initiation of the yeast G0 program requires Igo1 and Igo2, which antagonize activation of decapping of specific nutrient-regulated mRNAs.},
  author={Xuan Luo and Nicolas Talarek and Claudio De Virgilio},
  journal={RNA biology},
  year={2011},
  volume={8 1},
  pages={14-7}
}
Growth factors and essential nutrients are key controllers of eukaryotic cell proliferation. In their absence, cells may enter into a quiescent (G0) state. In yeast, nitrogen and/or carbon limitation causes downregulation of the conserved TORC1 and PKA signaling pathways and consequently activation of Rim15, a member of the PAS protein kinase family. Rim15 orchestrates the initiation of the G0 program in part by coordinating transcription of Msn2/4- and/or Gis1-dependent genes with… CONTINUE READING