Initiation of the Meiotic Prophase-to-metaphase Transition in Mammalian Oocytes

@inproceedings{Jaffe2010InitiationOT,
  title={Initiation of the Meiotic Prophase-to-metaphase Transition in Mammalian Oocytes},
  author={Laurinda A Jaffe and Rachael P Norris},
  year={2010}
}
Mammalian oocytes are arrested in meiotic prophase for prolonged periods, and then resume meiosis in response to luteinizing hormone from the pituitary, which binds to the somatic cells surrounding the oocyte. This chapter reviews current knowledge and questions about the molecular mechanisms that mediate communication between the somatic cells and oocyte to control the prophase-to-metaphase transition. Chapter 7 in "Oogenesis: The Universal Process", Marie-Helene Verlhac and Anne Villeneuve… CONTINUE READING