Initiation of proximal-distal patterning in the vertebrate limb by signals and growth.

  title={Initiation of proximal-distal patterning in the vertebrate limb by signals and growth.},
  author={Kimberly L Cooper and Jimmy Kuang-Hsien Hu and Derk ten Berge and Marian Fernandez-Teran and Marian A Ros and Clifford J Tabin},
  volume={332 6033},
Two broad classes of models have been proposed to explain the patterning of the proximal-distal axis of the vertebrate limb (from the shoulder to the digit tips). Differentiating between them, we demonstrate that early limb mesenchyme in the chick is initially maintained in a state capable of generating all limb segments through exposure to a combination of proximal and distal signals. As the limb bud grows, the proximal limb is established through continued exposure to flank-derived signal(s… CONTINUE READING

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