Initiation of nonselective alpha1-antagonist therapy and occurrence of hypotension-related adverse events among men with benign prostatic hyperplasia: a retrospective cohort study.

@article{Chrischilles2001InitiationON,
  title={Initiation of nonselective alpha1-antagonist therapy and occurrence of hypotension-related adverse events among men with benign prostatic hyperplasia: a retrospective cohort study.},
  author={Elizabeth A. Chrischilles and Linda Rubenstein and Jingdong Chao and Karl J. Kreder and Daniel B Gilden and Hemal B. Shah},
  journal={Clinical therapeutics},
  year={2001},
  volume={23 5},
  pages={
          727-43
        }
}
BACKGROUND Treatment of benign prostatic hyperplasia (BPH) with nonselective alpha1 antagonists such as terazosin, doxazosin, and prazosin results in blood pressure reduction due to vasodilation. OBJECTIVE Using claims data from a large Medigap plan, we examined the effect of initiating nonselective alpha1-antagonist therapy on the incidence of hypotension-related adverse events likely to be associated with vascular alpha-adrenoreceptor antagonism in patients with BPH. METHODS Medical and… CONTINUE READING
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