Initiation of myoblast/brown fat switch through a PRDM16-C/EBP-β transcriptional complex

  title={Initiation of myoblast/brown fat switch through a PRDM16-C/EBP-β transcriptional complex},
  author={S. Kajimura and P. Seale and K. Kubota and E. Lunsford and John V. Frangioni and S. Gygi and B. Spiegelman},
  pages={1154 - 1158}
  • S. Kajimura, P. Seale, +4 authors B. Spiegelman
  • Published 2009
  • Biology, Medicine
  • Nature
  • Brown adipose cells are specialized to dissipate chemical energy in the form of heat, as a physiological defence against cold and obesity. PRDM16 (PR domain containing 16) is a 140 kDa zinc finger protein that robustly induces brown fat determination and differentiation. Recent data suggests that brown fat cells arise in vivo from a Myf5-positive, myoblastic lineage by the action of PRDM16 (ref. 3); however, the molecular mechanisms responsible for this developmental switch is unclear. Here we… CONTINUE READING
    363 Citations
    Mir193b–365 is essential for brown fat differentiation
    • 256
    Prdm16 is required for the maintenance of brown adipocyte identity and function in adult mice.
    • 223
    • Highly Influenced
    EBF2 determines and maintains brown adipocyte identity.
    • 247
    • PDF
    RBM4a modulates the impact of PRDM16 on development of brown adipocytes through an alternative splicing mechanism.
    • Y. Chi, J. Lin
    • Biology, Medicine
    • Biochimica et biophysica acta. Molecular cell research
    • 2018
    • 1
    Functions of Prdm16 in thermogenic fat cells
    • 22


    PRDM16 controls a brown fat/skeletal muscle switch
    • 1,806
    • PDF
    Retinoblastoma protein functions as a molecular switch determining white versus brown adipocyte differentiation
    • 289
    • PDF