Initiation of myoblast/brown fat switch through a PRDM16-C/EBP-β transcriptional complex

@article{Kajimura2009InitiationOM,
  title={Initiation of myoblast/brown fat switch through a PRDM16-C/EBP-β transcriptional complex},
  author={S. Kajimura and P. Seale and K. Kubota and E. Lunsford and John V. Frangioni and S. Gygi and B. Spiegelman},
  journal={Nature},
  year={2009},
  volume={460},
  pages={1154 - 1158}
}
  • S. Kajimura, P. Seale, +4 authors B. Spiegelman
  • Published 2009
  • Biology, Medicine
  • Nature
  • Brown adipose cells are specialized to dissipate chemical energy in the form of heat, as a physiological defence against cold and obesity. PRDM16 (PR domain containing 16) is a 140 kDa zinc finger protein that robustly induces brown fat determination and differentiation. Recent data suggests that brown fat cells arise in vivo from a Myf5-positive, myoblastic lineage by the action of PRDM16 (ref. 3); however, the molecular mechanisms responsible for this developmental switch is unclear. Here we… CONTINUE READING
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