Initiation of multicellular differentiation in Dictyostelium discoideum is regulated by coronin A

@inproceedings{Vinet2014InitiationOM,
  title={Initiation of multicellular differentiation in Dictyostelium discoideum is regulated by coronin A},
  author={Adrien F. Vinet and Thomas Fiedler and Vera Studer and Romain Froquet and Anna Dardel and Pierre Cosson and Jean Pieters},
  booktitle={Molecular biology of the cell},
  year={2014}
}
Many biological systems respond to environmental changes by activating intracellular signaling cascades, resulting in an appropriate response. One such system is represented by the social amoeba Dictyostelium discoideum. When food sources become scarce, these unicellular cells can initiate a cAMP-driven multicellular aggregation program to ensure long-term survival. On starvation, the cells secrete conditioned medium factors that initiate cAMP signal transduction by inducing expression of genes… CONTINUE READING

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