Initiation of meiotic homologous recombination: flexibility, impact of histone modifications, and chromatin remodeling.


Meiotic recombination is initiated by the formation of DNA double-strand breaks (DSBs) catalyzed by the evolutionary conserved Spo11 protein and accessory factors. DSBs are nonrandomly distributed along the chromosomes displaying a significant (~400-fold) variation of frequencies, which ultimately establishes local and long-range "hot" and "cold" domains… (More)
DOI: 10.1101/cshperspect.a016527

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