Initiation of meiotic chromosome synapsis at centromeres in budding yeast.

  title={Initiation of meiotic chromosome synapsis at centromeres in budding yeast.},
  author={Tomomi Tsubouchi and Amy J MacQueen and G. Shirleen Roeder},
  journal={Genes & development},
  volume={22 22},
Previous studies of synaptonemal complex assembly in budding yeast have suggested that chromosome synapsis initiates at the sites of crossing over. The data presented here, however, indicate that centromeric regions are preferred sites for synapsis initiation. At early times during meiosis in wild type, the Zip1 protein (a major building block of the synaptonemal complex) localizes specifically to centromeric regions. As synapsis progresses and linear stretches of Zip1 are formed, the majority… CONTINUE READING
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Organization of the yeast Zip 1 protein within the central region of the synaptonemal complex

  • G. S. Roeder
  • J . Cell Biol .
  • 2000
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