Initiation of malignancy by duodenal contents reflux and the role of ezrin in developing esophageal squamous cell carcinoma.

@article{Ling2010InitiationOM,
  title={Initiation of malignancy by duodenal contents reflux and the role of ezrin in developing esophageal squamous cell carcinoma.},
  author={Zhi-Qiang Ling and Ken-ichi Mukaisho and Hiroto Yamamoto and Kuan-Hao Chen and Shinji Asano and Yoshio Araki and Hiroyuki Sugihara and Wei-Min Mao and Takanori Hattori},
  journal={Cancer science},
  year={2010},
  volume={101 3},
  pages={624-30}
}
Gastroesophageal reflux has recently been implicated as a causative factor in upper aerodigestive tract carcinogenesis. Esophageal squamous cell carcinomas (ESCCs) have developed in duodenal-content reflux animals without any known carcinogen present. We established a cell line, designated ESCC-DR, from a thoracic metastatic tumor in a reflux animal. To gain insight into the genomic alterations associated with duodenal content reflux-induced carcinogenesis, we first performed comparative… CONTINUE READING

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