Initiation of ionizing radiation-induced apoptosis: DNA damage-mediated or does ceramide have a role?

@article{Radford1999InitiationOI,
  title={Initiation of ionizing radiation-induced apoptosis: DNA damage-mediated or does ceramide have a role?},
  author={Ian R Radford},
  journal={International journal of radiation biology},
  year={1999},
  volume={75 5},
  pages={521-8}
}
  • Ian R Radford
  • Published 1999 in International journal of radiation biology
PURPOSE To critically review the data supporting membrane damage-induced increases in ceramide levels as the primary initiator of ionizing radiation-induced apoptosis and to point out that there is compelling evidence supporting the involvement of DNA damage in this process. CONCLUSIONS There is now a significant literature suggesting that irradiation of cells can quickly lead to a modest, transitory increase in the level of the putative second messenger ceramide. These results have been used… CONTINUE READING

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