Initiation of impaired outer segment degradation in vivo using an antisense oligonucleotide.

@article{Rakoczy1996InitiationOI,
  title={Initiation of impaired outer segment degradation in vivo using an antisense oligonucleotide.},
  author={Piroska Elizabeth Rakoczy and May C. Lai and Sarojini L. Vijayasekaran and Terry A Robertson and Lottie Rapp and John M. Papadimitriou and I C Constable},
  journal={Current eye research},
  year={1996},
  volume={15 1},
  pages={119-23}
}
This paper describes the first successful in vivo application of antisense DNA technology to induce the accumulation of photoreceptor outer segment derived debris in the retina. An antisense oligonucleotide (CatSC), which was previously demonstrated to be an effective tool to induce debris accumulation in vitro, was injected into the vitreous of pigmented… CONTINUE READING