Initiation of deregulated growth of multipotent progenitor cells by bcr-abl in vitro.

@article{Gishizky1992InitiationOD,
  title={Initiation of deregulated growth of multipotent progenitor cells by bcr-abl in vitro.},
  author={Mikhail L. Gishizky and Owen N Witte},
  journal={Science},
  year={1992},
  volume={256 5058},
  pages={836-9}
}
Expression of the bcr-abl oncogene in multipotent progenitor cells (MPPCs) is implicated as a key event in the development of chronic myelogenous leukemia. Bone marrow enriched for MPPCs was infected with a retrovirus that carried bcr-abl. The mixed-lineage colonies that resulted were responsive to growth factors and could differentiate. These cells later… CONTINUE READING