Initiation of cofilin activity in response to EGF is uncoupled from cofilin phosphorylation and dephosphorylation in carcinoma cells.

@article{Song2006InitiationOC,
  title={Initiation of cofilin activity in response to EGF is uncoupled from cofilin phosphorylation and dephosphorylation in carcinoma cells.},
  author={Xiaoyan Song and Xiaoming Chen and Hideki Yamaguchi and Ghassan Mouneimne and John S Condeelis and Robert J. Eddy},
  journal={Journal of cell science},
  year={2006},
  volume={119 Pt 14},
  pages={2871-81}
}
It has been demonstrated that the actin-severing activity of cofilin can be downregulated by LIM kinase (LIMK)-dependent phosphorylation at residue Ser3. Chemotactic stimulation in various cell types induces cofilin dephosphorylation, suggesting that cofilin activation in these cells occurs by a dephosphorylation mechanism. However, resting metastatic carcinoma cells have the majority of their cofilin in a dephosphorylated but largely inactive state. Stimulation with epidermal growth factor… CONTINUE READING