Initiation of autophagy and apoptosis by sonodynamic therapy in murine leukemia L1210 cells.

@article{Wang2013InitiationOA,
  title={Initiation of autophagy and apoptosis by sonodynamic therapy in murine leukemia L1210 cells.},
  author={Xiaobing Wang and Pan Wang and Kun Zhang and Xiaomin Su and Jie Hou and Quanhong Liu},
  journal={Toxicology in vitro : an international journal published in association with BIBRA},
  year={2013},
  volume={27 4},
  pages={
          1247-59
        }
}
Sonodynamic therapy (SDT) has shown great potential in target cancer therapy, but it induced cell death modes has not been fully investigated. This study was to examine autophagic and apoptotic responses to protoporphyrin IX (PpIX) mediated SDT in murine leukemia L1210 cells. After SDT, the occurrence of autophagy was identified by morphological observation and biochemical analysis. Meanwhile, the mitochondria dependent apoptosis pathway was examined to participate in SDT induced cell death… CONTINUE READING
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