Initiation of assembly of the cell envelope barrier structure of stratified squamous epithelia.

@article{Steinert1999InitiationOA,
  title={Initiation of assembly of the cell envelope barrier structure of stratified squamous epithelia.},
  author={Peter M. Steinert and Lyuben N. Marekov},
  journal={Molecular biology of the cell},
  year={1999},
  volume={10 12},
  pages={
          4247-61
        }
}
The cell envelope (CE) is a specialized structure that is important for barrier function in terminally differentiated stratified squamous epithelia. The CE is formed inside the plasma membrane and becomes insoluble as a result of cross-linking of constituent proteins by isopeptide bonds formed by transglutaminases. To investigate the earliest stages of assembly of the CE, we have studied human epidermal keratinocytes induced to terminally differentiate in submerged liquid culture as a model… CONTINUE READING

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