Initiation of assembly and association of the structural elements of a bacterial pilus depend on two specialized tip proteins.

@article{JacobDubuisson1993InitiationOA,
  title={Initiation of assembly and association of the structural elements of a bacterial pilus depend on two specialized tip proteins.},
  author={Françoise Jacob-Dubuisson and John M Heuser and Karen Dodson and Staffan J. Normark and Scott J Hultgren},
  journal={The EMBO journal},
  year={1993},
  volume={12 3},
  pages={
          837-47
        }
}
Uropathogenic Escherichia coli produce heteropolymeric surface fibers called P pili, which present an adhesin at their tip that specifically recognizes globoside receptors on the host uroepithelium. The initial attachment step is thought to be essential for pathogenesis. P pili are composite fibers consisting of a thin tip fibrillum joined end to end to a rigid helical rod. Here we show that the ordered assembly of these structures requires the activity of two proteins that are minor components… CONTINUE READING
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