Initiation of antigen receptor endocytosis and B lymphocyte activation lie on independent biochemical pathways.

Abstract

Peroxidase-conjugated anti-surface immunoglobulin (sIg) was used quantitatively to monitor endocytosis of crosslinked sIg on murine B lymphocytes. The role of biochemical second messengers in the initiation of endocytosis was assessed by employing several inhibitors. A novel peroxidase detection system was used and temperature-dependent decreases in sIg… (More)

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